|
Journal Article
Record |
| Author/Editor/Inventor: |
Singh Rana Pratap. Padmavathi Bandhuvula. Rao Araga Ramesha
[a]. |
| Institution: |
[a] Cancer Biology Laboratory, School of Life Sciences, Jawaharlal
Nehru University, New Delhi, 110067 India. |
| Country: |
India. |
| Title: |
Modulatory influence of Adhatoda vesica (Justicia adhatoda) leaf
extract on the enzymes of xenobiotic metabolism, antioxidant status and lipid
peroxidation in mice. |
| Source: |
Molecular and Cellular Biochemistry. [print] 213(1-2). October,
200X. 99-109. |
| Year of Publication: |
200X |
| Publication Type: |
Article. |
| ISSN: |
0300-8177 |
| Abstract: |
The effect of two different doses (50 and 100 mg/kg body wt/day
for 14 days) of 80% ethanolic extract of the leaves of Adhatoda vesica were
examined on drug metabolizing phase I and phase II enzymes, antioxidant enzymes,
glutathione content, lactate dehydrogenase and lipid peroxidation in the liver
of 8 weeks old Swiss albino mice. The modulatory effect of the extract was also
examined on extra-hepatic organs viz. lung, kidney and forestomach for the
activities of glutathione S-transferase, DT-diaphorase, superoxide dismutase and
catalase. Significant increase in the activities of acid soluble sulfhydry(-SH)
content, cytochrome P450, NADPH-cytochrome P450 reductase, cytochrome b5,
NADH-cytochrome b5 reductase, glutathione S-transferase (GST), DT-diaphorase
(DTD), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx)
and glutathione reductase (GR) were observed in the liver at both dose levels of
treatments. Adhatoda vesica acted as bifunctional inducer since it induced both
phase I and phase II enzyme systems. Both the treated groups showed significant
decrease in malondialdehyde (MDA) formation in liver, suggesting its role in
protection against prooxidant induced membrane damage. . . |
| Organisms: |
Adhatoda vesica (Acanthaceae); mouse (Muridae). |
| Parts, Structures & Systems of
Organisms: |
forestomach: digestive system; kidney: excretory system; leaf;
liver: digestive system; lung: respiratory system. |
| Chemicals & Biochemicals: |
Adhatoda vesica leaf extract: chemopreventive agent;
DT-diaphorase: antioxidant; catalase: antioxidant; compound: metabolism,
xenobiotic; cytochrome; glutathione S-transferase: antioxidant; glutathione
peroxidase; glutathione reductase; lipid: peroxidation; malondialdehyde;
superoxide dismutase: antioxidant. |
| Registry Numbers: |
9032-20-6: DT-DIAPHORASE; 9001-05-2: CATALASE; 50812-37-8:
GLUTATHIONE S-TRANSFERASE; 9013-66-5: GLUTATHIONE PEROXIDASE; 9001-48-3:
GLUTATHIONE REDUCTASE; 542-78-9: MALONDIALDEHYDE; 9054-89-1: SUPEROXIDE
DISMUTASE. |
| Gene Name: |
mouse superoxide dismutase gene |
| Methods & Equipment: |
supercritical carbon dioxide extraction: extraction
method. |
| Institutions & Organizations: |
Banyan Ayurvedic Botanicals: company/organization. |
| Diseases: |
Prooxidant-induced hepatic membrane damage: digestive system
disease, toxicity, prevention. |
| Major Concepts: |
Enzymology (Biochemistry and Molecular Biophysics). Metabolism.
Pharmacognosy (Pharmacology). |
| Concept Codes |
Enzymes/General and Comparative Studies; Coenzymes
[10802]
Biochemical Studies/General [10060]
Biochemical Studies/Lipids
[10066]
Metabolism/General Metabolism; Metabolic Pathways
[13002]
Digestive System/Physiology and Biochemistry [14004]
Urinary
System and External Secretions/Physiology and Biochemistry
[15504]
Respiratory System/Physiology and Biochemistry [16004]
Plant
Physiology, Biochemistry and Biophysics/Respiration, Fermentation
[51508]
Plant Physiology, Biochemistry and Biophysics/Enzymes
[51518]
Plant Physiology, Biochemistry and Biophysics/Metabolism
[51519]
Pharmacognosy and Pharmaceutical Botany [54000] |
| Biosystematic Codes |
Acanthaceae [25505]
Muridae [86375] |
| Super Taxa: |
Acanthaceae: Dicotyledones, Angiospermae, Spermatophyta, Plantae;
Muridae: Rodentia, Mammalia, Vertebrata, Chordata, Animalia. |
| Taxa Notes: |
Angiosperms; Animals; Chordates; Dicots; Mammals; Nonhuman
Mammals; Nonhuman Vertebrates; Plants; Rodents; Spermatophytes; Vascular Plants;
Vertebrates. |
| Miscellaneous Descriptors: |
herbal medicine. |
| Languages: |
English. |
| Summary Language: |
English. |
